Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease
Identifieur interne : 002435 ( Main/Exploration ); précédent : 002434; suivant : 002436Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease
Auteurs : C. Mytilineou [États-Unis] ; P. Werner [États-Unis] ; S. Molinari [États-Unis] ; A. Di Rocco [États-Unis] ; G. Cohen [États-Unis] ; D. Yahr [États-Unis]Source :
- Journal of Neural Transmission - Parkinson's Disease and Dementia Section [ 0936-3076 ] ; 1994-10-01.
Abstract
Summary: Whether or not a reported deficiency in brain mitochondrial complex I activity in Parkinson's disease represents a defect encompassing other organs or tissues has been a source of some controversy. We have examined mitochondrial respiration in fibroblasts from patients with Parkinson's disease by measuring the oxidative decarboxylation of [2-14C]pyruvate and [1,4-14C]succinate. We report that oxidation of pyruvate but not succinate was significantly reduced in fibroblasts from Parkinson patients when compared to healthy controls. These observations support the view that a widespread deficit in mitochondrial respiration exists in Parkinson's disease. Fibroblast cultures, moreover, are a source of affected proliferating cells, which can be used for in vitro studies of the nature of the respiratory defect and for testing of pharmacological interventions to correct the deficiency.
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DOI: 10.1007/BF02260943
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Y.</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission - Parkinson's Disease and Dementia Section</title><title level="j" type="abbrev">J Neural Transm Gen Sect</title><idno type="ISSN">0936-3076</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1994-10-01">1994-10-01</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="228">228</biblScope></imprint><idno type="ISSN">0936-3076</idno></series><idno type="istex">5CCD8084F66803233DB350DE7721F9280BE048DC</idno><idno type="DOI">10.1007/BF02260943</idno><idno type="ArticleID">Art7</idno><idno type="ArticleID">BF02260943</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0936-3076</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Whether or not a reported deficiency in brain mitochondrial complex I activity in Parkinson's disease represents a defect encompassing other organs or tissues has been a source of some controversy. We have examined mitochondrial respiration in fibroblasts from patients with Parkinson's disease by measuring the oxidative decarboxylation of [2-14C]pyruvate and [1,4-14C]succinate. We report that oxidation of pyruvate but not succinate was significantly reduced in fibroblasts from Parkinson patients when compared to healthy controls. These observations support the view that a widespread deficit in mitochondrial respiration exists in Parkinson's disease. Fibroblast cultures, moreover, are a source of affected proliferating cells, which can be used for in vitro studies of the nature of the respiratory defect and for testing of pharmacological interventions to correct the deficiency.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Mytilineou, C" sort="Mytilineou, C" uniqKey="Mytilineou C" first="C." last="Mytilineou">C. Mytilineou</name></noRegion><name sortKey="Cohen, G" sort="Cohen, G" uniqKey="Cohen G" first="G." last="Cohen">G. Cohen</name><name sortKey="Cohen, G" sort="Cohen, G" uniqKey="Cohen G" first="G." last="Cohen">G. Cohen</name><name sortKey="Di Rocco, A" sort="Di Rocco, A" uniqKey="Di Rocco A" first="A." last="Di Rocco">A. Di Rocco</name><name sortKey="Molinari, S" sort="Molinari, S" uniqKey="Molinari S" first="S." last="Molinari">S. Molinari</name><name sortKey="Werner, P" sort="Werner, P" uniqKey="Werner P" first="P." last="Werner">P. Werner</name><name sortKey="Yahr, D" sort="Yahr, D" uniqKey="Yahr D" first="D." last="Yahr">D. Yahr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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